natalbmikhalna (natalbmikhalna) wrote,
natalbmikhalna
natalbmikhalna

На всякий случай скопировала про "берберин".

Brief Summary:
Coronavirus disease 2019 (COVID-19) rapidly spread across China and throughout the world, causing hundreds of thousands died. Studies had shown that "cytokine storms" and subsequent multiple organ dysfunction (MODS) are important causes for disease progression and death in patients with COVID-19. Similar to SARS-CoV infection, SARS-CoV-2 would infect humans via binding of S-protein to angiotensin-converting enzyme 2 (ACE2), a host cell receptor, and the S protein is activated and cleaved by cellular transmembrane serine proteases, allowing the virus to release fusion peptides for membrane fusion. In addition to the lungs, ACE2 is also highly expressed in the esophagus, small intestine and colon, suggesting that the gut might also be an important target organ for SARS-CoV-2. About 8-16% of severe pneumonia cases confirmed with SARS-CoV-2 infection developed gastrointestinal symptoms such as abdominal pain, vomiting, and diarrhea. Moreover, the stool of patient with COVID-19 also positive by real-time reverse-transcriptase-polymerase-chain-reaction (rRT-PCR) assay. Furthermore, elevated faecal calprotectin was observed in patients with COVID-19 suggested an inflammatory response in the gut, which was significantly correlated with IL-6. For severe and critical cases, control "cytokine storms" and maintain intestinal microenvironment balance have been included into the Diagnosis and Treatment Guideline of patients with COVID-19 (Edition 7). Berberine is a quaternary ammonium alkaloid isolated from rhizoma coptidis. It is often used in treatment of infectious diarrhea by bacteriostasis and inhibition of intestinal gland secretion. Berberine has also been found to have a role in intestinal immune regulation, inhibiting both AP-1 and NF- B, the key factors in cell signal transduction, and reducing the inflammatory response. Investigators conducted a prospective randomized controlled clinical trial to investigate the effects of berberine on intestinal function, serum concentrations of the inflammatory biomarkers, and organ function in severe patients with SARS-CoV-2 infection.



Condition or disease


Intervention/treatment


Phase
BerberineCOVID-19 Drug: BerberineDrug: Montmorrillonite Phase 4

Detailed Description:
Patients aged 18-80 years who confirmed with COVID-19 and classified as severe were enrolled in the study, and then separated randomly into two groups: a berberine group (B group) and a control group (C group). The diagnostic criteria for severe cases are in accordance with the Diagnosis and Treatment Guideline of patients with COVID-19 issued by the National Health Commission of the People's Republic of China (Edition 7). In general, patients diagnosed with COVID-19 pneumonia must also meet any of the following criteria: appears shortness of breath, respiratory rate (RR) ≥ 30 times/min; SPO2 ≤ 93% at rest; the ratio of partial oxygen pressure of arterial blood (PaO2) to oxygen absorption concentration (FiO2) ≤ 300mmHg (1mmHg=0.133KPa); pulmonary imaging showed the lesion progression >50% within 24-48 hours. All enrolled patients were given general support therapy, oxygen therapy, antiviral drugs, in combination with antibiotics and small doses of glucocorticoids if necessary, nutritional and organ function support. Patients in the berberine group (B group) were given berberine 0.3g tid orally or tube feed daily, while patients in the control group (C group) were given montmorilonite orally if they presence of diarrhea. The duration of the study intervention was 14 days and followed up to discharge. Investigators record general information about patients at admission, including age, gender, age, exposure history, time from onset of symptoms to hospital, APACHE II score, the presentation of X-ray, comorbidity, mechanical ventilation, fever or not,gastrointestinal symptoms. Investigators also evaluate the gastrointestinal function daily,including gastrointestinal symptoms (nausea, vomiting, abdominal pain, abdominal distension or diarrhoea), frequency of diarrhea, the characteristics of stool (Bristol scal). Peripheral blood are collected on day 1,3, 7 and 14 after admission to determine the level of interleukin-6 (IL-6), interleukin-1β (IL-1β), interleukin-10 (IL-10) and tumor necrosis factor (TNF-α). Laboratory tests are also performed to evaluate leucocyte, c-reactive protein (CRP), and procalcitonin (PCT) levels at the same time. Glutamate transaminase (ALT), glutamate transaminase (AST), urea nitrogen (Bun), creatinine, prothrombin time (PT), partially activated prothrombin time (APTT), and Sequential Organ Failure Assessment (SOFA) score are used to evaluate organ function on day 1,3, 7 and 14 after admission. Investigators also record the adverse events associated with the drug, length of stay and the prognosis at discharge. The patients are blinded to the group allocation. Two physicians are responsible for data processing, one is responsible for recording and collecting, and the other is responsible for checking, and they are all blind to the research.
Study Design
Go to


https://en.wikipedia.org/wiki/Berberine

Поозже буду разбираться...

Разобралась.

Кофермент Q (МНН: Ubidecarenone, Убидекаренон; также известен как кофермент Q10, убихинон, ubiquinone, coenzyme Q10, coenzyme Q) — это группа коферментов —  https://ru.wikipedia.org/wiki/Убиквитин

А на картинке мы можем видеть наш Лизин!!! (жёлтенькие кончики у белка). Вот он где нарисовался! Про лизин писала, также и на тему нашего ковида.
"AP-1 and NF- B" - эти две молекулы постоянно ошиваются в клетках, одна молекула получает сигнал, активируется и передаёт сигнал другой. Вторая влияет на гены, и начинается воспаление. Клетка воспаляется, а ещё передаёт сигналы другим, чтобы они тоже "возгорались". Пожар!-Горим!. Цитокиновый шторм.
Эту сигнальную "эстафету" запускает фосфориляция, а можно "отменить-задавить" Убихинацией", а там очень не последнюю роль играет наш Лизин.
Есть таблетки Кофермент или Соэнзим Кью-10. Продаётся такой. Вот в нём аминокислота Лизин и присутствует.

И Берберин, содержащийся в барбарисе (это понятно;) делает то же самое - не даёт разгореться пожару в кишечнике, от которого тоже зависит пожар во всём организме, влияя на те же сигнальные молекулы. От кишечника вообще очень многое зависит.
" Berberine has also been found to have a role in intestinal immune regulation, inhibiting both AP-1 and NF- B, the key factors in cell signal transduction, and reducing the inflammatory response."
Пришлось долго прослеживать цепочку, пока всё не встало на свои места. С результатом "расследования" я себя и поздравляю.;))))))
(И кстати, он, кью-10, делается из холестерина, вернее, по цепочке превращений молекул одна в другую, он находится позже холестерина. Понижаете холестерин - не из чего производить убихинон. Его настойчиво советуют принимать в таблетках людям на статинах, понижающих холестерин. Про статины говорят, что они "понижают воспаление" - ага, щас! Получается, что и тут Убихинон кью-10 работает и понижает. Никто не рискует принимать статины без кью-10, потому и живы ещё. Как меня всякое-такое надувательство бесит!)
Tags: не болеть, чума19
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